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Product Details:
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| Product Name: | Sorafenib Tosylate | Export Markets: | Global |
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| Purity: | 99% | Policy: | Re-Shipping Policy |
| Supply: | In Stock | Shipment: | FedEx, EMS, HKEMS, TNT, DHL, UPS |
| Appearance: | White Powder | Contact: | Holybiological04@holybiological.com |
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Raw Material Pharmaceuticals Anti-cancer Nexavar Sorafenib Tosylate
Product Name: Sorafenib tosylate
CAS Number: 475207-59-1
Formula: C21H16ClF3N4O3. C7H8SO3
Molecular Weight: 637.03
Melting Point:202-204°C
Storage Temp. -20°C Freezer
Appearance: Light brown solid powder
Loss on drying: Less than 0.5%
Heavy metals: Less than 10ppm
Total impurities: Less than 1.0%
Content: 99%
Usage: Toluenesulfonic Sorafenib is a novel multi-target anticancer drugs, can act simultaneously on tumor cells and tumor blood vessels. It has a dual anti-tumor effects: Either by blocking the RAF / MEK / ERK-mediated cell signaling.
Description:
Sorafenib (co-developed and co-marketed by Bayer and Onyx Pharmaceuticals as Nexavar), is a kinase inhibitor drug approved for the treatment of primary kidney cancer (advanced renal cell carcinoma), advanced primary liver cancer (hepatocellular carcinoma), and radioactive iodine resistant advanced thyroid carcinoma.
Sorafenib treatment induces autophagy, which may suppress tumor growth. However, autophagy can also cause drug resistance.
Medical uses:
At the current time sorafenib is indicated as a treatment for advanced renal cell carcinoma (RCC), unresectable hepatocellular carcinomas (HCC) and thyroid cancer
| product Name | Sorafenib tosylate |
| Synonyms | SORAFENIB-D3; 4-Methyl-3-((4-(3-pyridinyl)-2-pyrimidinyl)amino)-N-(5-(4-methyl-1H-imidazol-1-yl)-3-(trifluoromethyl)phenyl)benzamide monomethanesulfonate; N-[4-Chloro-3-(trifluoromethyl)phenyl]-N'-[4-[2-(N-methylcarbamoyl)-4-pyridyloxy]phenyl]urea Tolsylate |
| Molecular Formula | C21H16ClF3N4O3・C7H8SO |
| Molecular Weight | 637.03 |
| CAS Registry Number | 4750207-59-1 |
| Storage Temp | -20°C Freezer |
| Melting Point | 202-204°C |
| Loss on drying | Less than 0.5% |
| Heavy metals | Less than 10ppm |
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