|Appearance:||White Powder||Application:||Inhibitor Drug|
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Anti-cancer Pharmaceuticals White Powder Inhibitor Drug Nexavar Sorafenib Tosylate
Synonyms: SORAFENIB TOSYLATE;Sorafenib & its intermediates;Sorafinib mesylate;4-Methyl-3-((4-(3-pyridinyl)-2-pyrimidinyl)amino)-N-(5-(4-methyl-1H-imidazol-1-yl)-3-(trifluoromethyl)phenyl)benzamide monomethanesulfonate;Sorafenib Tosylate(Bay 43-9006,Nexavar);2-PyridinecarboxaMide, 4-[4-[[[[4-chloro-3-(trifluoroMethyl)phenyl]aMino]carbonyl]aMino]phenoxy]-N-Methyl-, 4-Methylbenzenesulfonate;Sorafenib Tosylate (Nexavar);Sorafenib (Nexavar)
Product Categories: Bay 43-9006
Usage Sorafenib Tosylate (Bay 43-9006, Nexavar) is a small molecular inhibitor of VEGFR, PDGFR, c-Raf and B-Raf with IC50s of 18 nM, 10 nM, 3 nM and 15 nM, respectively.
Usage Sorafenib Tosylate (Bay 43-9006) is a multikinase inhibitor of Raf-1, B-Raf and VEGFR-2 with IC50 of 6 nM, 22 nM and 90 nM, respectively
Sorafenib is a kinase inhibitor drug approved for the treatment of primary kidney cancer (advanced renal cell carcinoma), advanced primary liver cancer (hepatocellular carcinoma), and radioactive iodine resistant advanced thyroid carcinoma.
At the current time sorafenib is indicated as a treatment for advanced renal cell carcinoma (RCC), unresectable hepatocellular carcinomas (HCC) and thyroid cancer
|product Name||Sorafenib tosylate|
|Synonyms||SORAFENIB-D3; 4-Methyl-3-((4-(3-pyridinyl)-2-pyrimidinyl)amino)-N-(5-(4-methyl-1H-imidazol-1-yl)-3-(trifluoromethyl)phenyl)benzamide monomethanesulfonate; N-[4-Chloro-3-(trifluoromethyl)phenyl]-N'-[4-[2-(N-methylcarbamoyl)-4-pyridyloxy]phenyl]urea Tolsylate|
|CAS Registry Number||475207-59-1;4750207-59-1|
toluenesulfonic Sorafenib is a novel multi-target anticancer drugs, can act simultaneously on tumor cells and tumor blood vessels. It has a dual The anti-tumor effect: either by blocking the RAF / MEK / ERK-mediated cell signaling pathways and direct inhibition of tumor cell proliferation, but also By inhibiting VEGF and platelet-derived Health growth factor (PDGF) receptors and block the formation of tumor angiogenesis, indirectly inhibit the growth of tumor cells
Sorafenib is used for:
Treating certain types of kidney, liver or thyroid cancer. It may also be used for other conditions as determined by your doctor.
Sorafenib is a multikinase inhibitor. It works by helping to stop cancer cells from growing.
Do NOT use sorafenib if:
you are allergic to any ingredient in sorafenib
you have a certain type of irregular heartbeat (congenital long QT syndrome)
you have a certain type of lung cancer (squamous cell) and are taking carboplatin and paclitaxel
Contact your doctor or health care provider right away if any of these apply to you.
Before using sorafenib:
Some medical conditions may interact with sorafenib. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:
if you are pregnant, planning to become pregnant, or are breast-feeding
if you are able to become pregnant
if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
if you have allergies to medicines, foods, or other substances
you have heart failure or other heart problems (eg, irregular heartbeat, disease of the blood vessels in the heart, a recent heart attack)
if you have chest pain; high blood pressure; bleeding problems; blood electrolyte problems (eg, low blood calcium, magnesium, or potassium levels); stomach or bowel problems (eg, tearing); or liver, kidney, or thyroid problems
if you have or are being treated for lung cancer
if you have recently had or will be having surgery
if you take any medicine that may increase the risk of a certain type of irregular heartbeat (prolonged QT interval). Check with your doctor or pharmacist if you are unsure if any of your medicines may increase the risk of this type of irregular heartbeat
Some MEDICINES MAY INTERACT with sorafenib. Tell your health care provider if you are taking any other medicines, especially any of the following:
Warfarin because risk of bleeding may be increased
Carbamazepine, dexamethasone, hydantoins (eg, fosphenytoin, phenytoin), nevirapine, oral neomycin, phenobarbital, primidone, rifamycins (eg, rifabutin, rifampin), or St. John's wort because they may decrease sorafenib's effectiveness
This may not be a complete list of all interactions that may occur. Ask your health care provider if sorafenib may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.
How to use sorafenib:
Use sorafenib as directed by your doctor. Check the label on the medicine for exact dosing instructions.
An extra patient leaflet is available with sorafenib. Talk to your pharmacist if you have questions about this information.
Take sorafenib on an empty stomach at least 1 hour before or 2 hours after eating.
Swallow sorafenib whole. Do not break, crush, or chew before swallowing.
Take sorafenib with a full glass of water (8 oz [240 mL]).
Continue to take sorafenib even if you feel well. Do not miss any doses.
If you miss a dose of sorafenib, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.
Ask your health care provider any questions you may have about how to use sorafenib.
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